CT和MRI图像一键配准融合
济南军区总医院神经外科 王奎重 博士 3D Slicer有强大的配准融合功能，既往推出的General Registration (BRAINS)模块虽然配准精度高，但设置参数较多，过程复杂，初学者难以掌握。本文介绍另外一个配准模块Elastix，可以对CT和MRI图像一键配准。
1.下载并打开3D Slicer4.8.1软件，安装扩展模块Elastix。关闭并重新打开3D Slicer，载入CT（6 1）和MRI（Ax 3D T1BRAVO）图像数据。在前景和背景窗口中可以看到CT和MRI图像未重叠。
2.打开registration-general registration(Elastix)模块，在fixed volume栏里选择磁共振数据（Ax 3D T1BRAVO），moving volume栏内选择CT数据（6 1），设置输出volume和transform名字，其余为默认选项。点击Apply。
3.稍等片刻，即可配准成功。在窗口前景中选择磁共振数据（Ax 3D T1BRAVO），背景中选择新输出的数据volume，调节滑动条透明度，即可显示CT和MRI图像配准效果。
4.最后别忘了保存，可见新生成volume和transform两个文件将存在其默认文件夹中，时间长了容易变成垃圾文件，可以更改路径存入想要的文件夹。
5.若要进行图像融合，可以打开Add Scalar Volumes模块，输入磁共振（Ax 3D T1BRAVO）和数据volume，设置新融合的数据名字，点击Apply即可融合在一起。
图像配准和融合是两个不同的概念，配准是两张图像的空间位置改变使其重叠，但还是各自原来的图像。融合是两张图像融为一体不能分开，有关融合方法我以前有过介绍，这里不再赘述，实际应用中只需要配准功能就足够了。本文介绍了利用3D Slicer对CT和MRI图像一键配准融合，可以快速实现同一患者不同模式图像的融合，操作过程中也可以调节不同参数及选择不同的预设模板（preset）。注意：对于影像变化较大的两组图像配准时，如患者做MRI时由于线圈卡压导致脸部固定时变形，和CT配准后就会显示颅骨不能重叠，虽然面部及头皮软组织能较好重叠，但颅骨和颅内结构重叠欠佳。这时preset里最好选择刚性配准，即generic rigid (all)选项，通过刚性配准，颅骨可以较好重叠，颅内结构也能获得较好配准，但面部及头皮软组织重叠就会欠佳。笔者在实际应用中发现不同机器扫描图像通过3D Slicer打开时甚至不能在一个视野中,这可以通过粗略变换图像坐标实现；即便同一个病人扫描的MRI数据，由于扫描时间长不同序列间还是有细微的位置改变，而通过3D Slicer配准功能，可以消除这些肉眼所见到的位置改变。
注：本文仅供个人学习交流，不妥之处恳请大家批评指正。未经本人同意不得擅自转载及他用，有关参照本文产生的纠纷及法律后果本人概不负责。
About Author
admin
Add a Comment
要发表评论，您必须先登录。
Fantastic site you have here but I was curious if you knew of
any discussion boards that cover the same topics discussed in this article?
I’d really love to be a part of group where I can get advice from other experienced people that share the same interest.
If you have any suggestions, please let me know. Kudos!
I am genuinely glad to read this web site posts which contains plenty
of useful facts, thanks for providing such statistics.
Heya i am for the first time here. I found this board and I find It really useful & it helped me out a lot.
I hope to give something back and help others like you helped me.
I pay a quick visit everyday a few blogs and information sites to read posts, however this webpage
presents feature based posts.
What’s up to every single one, it’s genuinely a nice for me to visit this site, it includes priceless Information.
This article is actually a fastidious one it assists new web viewers, who are wishing in favor
of blogging.
Thank you for the good writeup. It in fact was a amusement account it.
Look advanced to far added agreeable from you! However, how can we communicate?
Normally I do not learn article on blogs, however I would like
to say that this write-up very pressured me to take
a look at and do it! Your writing style has been amazed me.
Thank you, quite great article.
What i do not understood is in reality how you
are no longer really a lot more neatly-preferred than you may be now.
You’re very intelligent. You understand thus considerably in the case of this matter, produced me personally imagine it from so many varied angles.
Its like men and women are not involved unless it’s one thing to do with Lady gaga!
Your personal stuffs nice. At all times handle it up!
I don’t even know the way I stopped up right here, however I
thought this submit used to be good. I don’t understand who you might be but
certainly you’re going to a famous blogger in the event
you are not already. Cheers!
Hey There. I found your blog using msn. This is an extremely well written article.
I’ll be sure to bookmark it and come back to read more of your useful info.
Thanks for the post. I’ll definitely return.